Genome location: Pf3D7_13_v3:1,622,988..1,625,706(+)
Genome classification: Core
Product Description: mitochondrial pyruvate carrier protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Process | GO:0006850 | mitochondrial pyruvate transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.23 | 0.85 |
| Schizont | no data | 0.14 | 0.90 |
| Gametocyte | no data | 0.36 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1340800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.119 | MFS: -3.235 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDS8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102458
Most Similar Human Ortholog: Q5TI65
TM-align score: 0.92 | RMSD: 1.34
Seq Identity: 0.44 | Length: 66 / 106
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000060762 | mitochondrial pyruvate carrier 1 |
| ENSG00000238205 | mitochondrial pyruvate carrier 1 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 165
Non-coding: 155 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 106 | Molecular Weight (kDa): 12.259
UniProt ID(s): Q8IDS8
PDB ID(s): None
Isoelectric Point: 10.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005336 | Mitochondrial pyruvate carrier |
| PFam | PF03650 | Mitochondrial pyruvate carrier |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 25032958 | BCKDH: the missing link in apicomplexan mitochondrial metabolism is required forfull virulence of Toxoplasma gondii and Plasmodium berghei. | Oppenheim RD, Creek DJ, ..., Soldati-Favre D | 10.1371/journal.ppat.1004263 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |