About Gene List

PF3D7_1340900 (PiT)

Genome location: Pf3D7_13_v3:1,625,796..1,629,643(+)

Genome classification: Core

Function and Localization

Product Description: sodium-dependent phosphate transporter

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005887 integral component of plasma membrane
Component GO:0005886 plasma membrane
Function GO:0005315 inorganic phosphate transmembrane transporter activity
Process GO:0035435 phosphate ion transmembrane transport
Process GO:0006817 phosphate ion transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.16 0.53
Trophozoite expressed 1.14 0.43
Schizont expressed 1.16 0.40
Gametocyte expressed 1.00 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.238 | MFS: -2.841 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDS7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
Q08357 Sodium-dependent phosphate transporter 2 OrthoDB CHEMBL4170023
Q8WUM9 Sodium-dependent phosphate transporter 1 OrthoDB CHEMBL4170023CHEMBL4159390

Orthology Information

Ortholog Group (OrthoMCL): OG6_100354

Most Similar Human Ortholog: E5RGG8

TM-align score: 0.87 | RMSD: 1.18

Seq Identity: 0.42 | Length: 76 / 687

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000144136 solute carrier family 20 member 1
ENSG00000168575 solute carrier family 20 member 2

Protein Information

Protein Length: 687 | Molecular Weight (kDa): 75.295

UniProt ID(s): Q7YUD6, Q8IDS7

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001204 Phosphate transporter
PFam PF01384 Phosphate transporter
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 48 22 50
disruptive 22 39 24 59
missense 8 34 19 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 81 30 47
disruptive 30 76 34 105
missense 12 61 30 78

PlasmoDB Total SNPs: 247

Non-coding: 178 | Synonymous: 33 | Nonsynonymous: 36 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
17006451 Sodium-dependent uptake of inorganic phosphate by the intracellular malariaparasite. Saliba KJ, Martin RE, ..., Kirk K 10.1038/nature05149
38394375 Methods of sampling malaria vectors and their reliability in estimatingentomological indices in Africa Degefa T, Yewhalaw D, Yan G 10.1093/jme/tjae015