Product Description: 60S ribosomal protein L18, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.16 | 0.51 |
| Trophozoite | expressed | 1.41 | 0.37 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.43 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1341200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.117 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1354400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDS6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101208
Most Similar Human Ortholog: M0R3D6
TM-align score: 0.96 | RMSD: 1.10
Seq Identity: 0.50 | Length: 141 / 184
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105640 | ribosomal protein L18a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 139
Non-coding: 113 | Synonymous: 20 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 184 | Molecular Weight (kDa): 21.746
UniProt ID(s): Q8IDS6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021138 | 60S ribosomal protein L18a/ L20, eukaryotes |
| InterPro | IPR023573 | Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A |
| InterPro | IPR028877 | 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a |
| PFam | PF01775 | Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A |
| Superfamily | SSF160374 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |