Product Description: 60S ribosomal protein L18-2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.05 | 0.29 |
| Trophozoite | expressed | 2.47 | 0.12 |
| Schizont | expressed | 0.59 | 0.69 |
| Gametocyte | expressed | 1.79 | 0.22 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1341300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.929 | MFS: -2.826 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5G3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100803
Most Similar Human Ortholog: Q07020
TM-align score: 0.97 | RMSD: 0.99
Seq Identity: 0.58 | Length: 186 / 187
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000063177 | ribosomal protein L18 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 9 | 7 |
| disruptive | 0 | 3 | 5 | 16 |
| missense | 0 | 3 | 5 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 29 | 4 | 18 |
| disruptive | 3 | 14 | 15 | 39 |
| missense | 1 | 11 | 13 | 32 |
PlasmoDB Total SNPs: 128
Non-coding: 124 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 187 | Molecular Weight (kDa): 21.454
UniProt ID(s): C0H5G3
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000039 | Ribosomal protein L18e |
| InterPro | IPR021131 | Ribosomal protein L18e/L15P |
| InterPro | IPR021132 | Ribosomal protein L18e, conserved site |
| InterPro | IPR036227 | Ribosomal L18e/L15P superfamily |
| PFam | PF17135 | Ribosomal protein L18e/L15P |
| Superfamily | SSF52080 | Ribosomal L18e/L15P superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |