Genome location: Pf3D7_13_v3:1,639,020..1,641,267(+)
Genome classification: Core
Product Description: inner membrane complex suture component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.40 | 0.76 |
| Gametocyte | expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1341500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.239 | MFS: -2.623 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1354600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1354600)
Modification: Disrupted | RMgm-3664
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8W3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 6 | 32 |
| disruptive | 28 | 92 | 50 | 123 |
| missense | 13 | 64 | 47 | 98 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 47 | 15 | 37 |
| disruptive | 53 | 187 | 66 | 152 |
| missense | 25 | 151 | 56 | 101 |
PlasmoDB Total SNPs: 112
Non-coding: 33 | Synonymous: 49 | Nonsynonymous: 30 | Stop Codon: 0
Protein Length: 508 | Molecular Weight (kDa): 58.843
UniProt ID(s): A0A5K1K8W3
PDB ID(s): None
Isoelectric Point: 7.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 25691595 | Novel components of the Toxoplasma inner membrane complex revealed by BioID. | Chen AL, Kim EW, ..., Bradley PJ | 10.1128/mBio.02357-14 |
| 26573460 | Producing human ceramide-NS by metabolic engineering using yeast Saccharomycescerevisiae | Murakami S, Shimamoto T, ..., Funato K | 10.1038/srep16319 |
| 32205408 | Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by aCDC55-Dependent Mechanism | Matmati N, Hassan BH, ..., Hannun YA | 10.1128/MCB.00340-19 |
| 24196832 | The protein kinase Sch9 is a key regulator of sphingolipid metabolism inSaccharomyces cerevisiae | Swinnen E, Wilms T, ..., Winderickx J | 10.1091/mbc.E13-06-0340 |
| 24973565 | Sphingolipids and mitochondrial function in budding yeast | Spincemaille P, Matmati N, ..., Thevissen K | 10.1016/j.bbagen.2014.06.015 |