PF3D7_1341800 (IMC1k)

Genome location: Pf3D7_13_v3:1,645,735..1,648,368(-)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1k, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	possibly expressed	0.23	0.84
Gametocyte	expressed	0.49	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1341800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.269 | MFS: -2.726 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1360600)

Modification: Tagged | RMgm-4495

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDS1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174458

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	14	36
disruptive	10	53	31	80
missense	10	52	31	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	42	18	34
disruptive	20	113	51	140
missense	19	105	42	106

PlasmoDB Total SNPs: 173

Non-coding: 148 | Synonymous: 11 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 462 | Molecular Weight (kDa): 53.721

UniProt ID(s): Q8IDS1

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022086	Inner membrane complex protein
PFam	PF12314	Inner membrane complex protein
Superfamily	N/A	N/A