PF3D7_1341900

Genome location: Pf3D7_13_v3:1,649,035..1,651,981(-)

Genome classification: Core

Function and Localization

Product Description: V-type proton ATPase subunit D, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020020	food vacuole
Component	GO:0033176	proton-transporting V-type ATPase complex
Component	GO:0005774	vacuolar membrane
Component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
Component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain
Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism
Process	GO:1902600	proton transmembrane transport
Process	GO:0007035	vacuolar acidification

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.10	0.95
Trophozoite	expressed	0.36	0.78
Schizont	expressed	0.14	0.90
Gametocyte	expressed	0.57	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1341900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.354 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDS0

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.3.14	H+-transporting two-sector ATPase	No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101069

Most Similar Human Ortholog: H0YJS0

TM-align score: 0.94 | RMSD: 1.46

Seq Identity: 0.36 | Length: 119 / 247

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100554	ATPase H+ transporting V1 subunit D

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	1	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 238

Non-coding: 229 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 27.801

UniProt ID(s): Q8IDS0

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002699	ATPase, V1 complex, subunit D
PFam	PF01813	ATPase, V1 complex, subunit D
Superfamily	N/A	N/A