Product Description: 40S ribosomal protein S6
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 2.46 | 0.18 |
| Trophozoite | expressed | 2.75 | 0.10 |
| Schizont | expressed | 0.74 | 0.62 |
| Gametocyte | expressed | 1.45 | 0.34 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1342000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.986 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1355100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDR9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100737
Most Similar Human Ortholog: P62753
TM-align score: 0.97 | RMSD: 0.90
Seq Identity: 0.54 | Length: 248 / 306
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137154 | ribosomal protein S6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 2 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 155
Non-coding: 129 | Synonymous: 18 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 306 | Molecular Weight (kDa): 35.384
UniProt ID(s): Q8IDR9
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001377 | Ribosomal protein S6e |
| InterPro | IPR018282 | Ribosomal protein S6e, conserved site |
| PFam | PF01092 | Ribosomal protein S6e |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |