PF3D7_1342200

Genome location: Pf3D7_13_v3:1,660,640..1,663,930(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.27	0.84
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1342200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.014 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8X3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532304

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	47	36	65
disruptive	69	195	99	218
missense	31	159	86	172

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	96	47	93
disruptive	116	377	152	278
missense	59	293	123	197

PlasmoDB Total SNPs: 156

Non-coding: 34 | Synonymous: 66 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 972 | Molecular Weight (kDa): 119.243

UniProt ID(s): A0A5K1K8X3

PDB ID(s): None

Isoelectric Point: 9.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A