PF3D7_1342300

Genome location: Pf3D7_13_v3:1,664,354..1,665,907(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	expressed	0.40	0.76
Schizont	possibly expressed	0.21	0.87
Gametocyte	possibly expressed	0.29	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1342300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -3.302 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K972

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_152344

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	16	8	23
disruptive	3	15	17	36
missense	3	13	16	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	32	19	22
disruptive	5	56	34	88
missense	3	44	33	57

PlasmoDB Total SNPs: 84

Non-coding: 58 | Synonymous: 9 | Nonsynonymous: 15 | Stop Codon: 2

Protein Information

Protein Length: 263 | Molecular Weight (kDa): 30.943

UniProt ID(s): A0A5K1K972

PDB ID(s): None

Isoelectric Point: 8.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	PF13424	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily