Genome location: Pf3D7_13_v3:1,665,798..1,668,854(-)
Genome classification: Core
Product Description: casein kinase II beta chain
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0005956 | protein kinase CK2 complex |
| Function | GO:0005515 | protein binding |
| Function | GO:0019887 | protein kinase regulator activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.63 | 0.70 |
| Trophozoite | expressed | 1.13 | 0.43 |
| Schizont | expressed | 0.27 | 0.83 |
| Gametocyte | expressed | 0.54 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1342400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.043 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0943200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDR5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P67870 | Casein kinase II subunit beta | OrthoDB | US9303033, N47, Table 58A, Compound 11US9303033, Q47, Table 58A, Compound 14BDBM220085US9303033, C1, Table 2A, Compound 1... |
Ortholog Group (OrthoMCL): OG6_100687
Most Similar Human Ortholog: P67870
TM-align score: 0.85 | RMSD: 2.55
Seq Identity: 0.40 | Length: 208 / 385
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000204435 | casein kinase 2 beta |
| ENSG00000230700 | casein kinase 2 beta |
| ENSG00000232960 | casein kinase 2 beta |
Protein Length: 385 | Molecular Weight (kDa): 45.285
UniProt ID(s): Q8IDR5
PDB ID(s): None
Isoelectric Point: 3.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000704 | Casein kinase II, regulatory subunit |
| InterPro | IPR035991 | Casein kinase II subunit beta-like |
| PFam | PF01214 | Casein kinase II, regulatory subunit |
| Superfamily | SSF57798 | Casein kinase II subunit beta-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 35 | 9 | 19 |
| disruptive | 20 | 55 | 26 | 58 |
| missense | 5 | 22 | 16 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 39 | 16 | 27 |
| disruptive | 33 | 94 | 48 | 111 |
| missense | 10 | 44 | 37 | 58 |
PlasmoDB Total SNPs: 180
Non-coding: 144 | Synonymous: 32 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19114502 | Functional analysis of protein kinase CK2 of the human malaria parasitePlasmodium falciparum. | Holland Z, Prudent R, ..., Doerig C | 10.1128/EC.00334-08 |
| 22293287 | Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assemblypathway. | Dastidar EG, Dayer G, ..., Doerig C | 10.1186/1741-7007-10-5 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31723180 | Mapping and functional analysis of heterochromatin protein 1 phosphorylation inthe malaria parasite Plasmodium falciparum. | Bui HTN, Niederwieser I, ..., Voss TS | 10.1038/s41598-019-53325-9 |