PF3D7_1342900 (AP2-HS)

Genome location: Pf3D7_13_v3:1,682,054..1,694,167(-)

Genome classification: Core

Function and Localization

Product Description: AP2 domain transcription factor AP2-HS

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003700	DNA-binding transcription factor activity
Function	GO:0043565	sequence-specific DNA binding
Process	GO:0006355	regulation of transcription, DNA-templated
Process	GO:0009408	response to heat
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.96	0.60
Trophozoite	expressed	1.27	0.41
Schizont	expressed	0.46	0.77
Gametocyte	expressed	1.61	0.28

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1342900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.975 | #Insertions: 13

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	31	173	97	206
disruptive	177	611	315	720
missense	101	506	270	605

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	56	321	146	230
disruptive	348	1214	518	1031
missense	200	976	425	707

PlasmoDB Total SNPs: 647

Non-coding: 49 | Synonymous: 287 | Nonsynonymous: 308 | Stop Codon: 3

Protein Information

Protein Length: 3858 | Molecular Weight (kDa): 455.993

UniProt ID(s): C0H5G5, O15792, Q9Y1C8, Q9Y1C9, Q9Y1D0, Q9Y1D1

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001471	AP2/ERF domain
PFam	PF00847	AP2/ERF domain
Superfamily	SSF141571	N/A

PMID	Title	Authors	DOI/Link
34400833	A heat-shock response regulated by the PfAP2-HS transcription factor protectshuman malaria parasites from febrile temperatures.	Tinto-Font E, Michel-Todo L, ..., Cortes A	10.1038/s41564-021-00940-w
37204422	Genomic variation during culture adaptation of genetically complex Plasmodiumfalciparum clinical isolates	Claessens A, Stewart LB, ..., Conway DJ	10.1099/mgen.0.001009