PF3D7_1343100

Genome location: Pf3D7_13_v3:1,699,588..1,702,492(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.40	0.76
Schizont	expressed	1.04	0.49
Gametocyte	expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1343100

Resistome Missense Mutations: M6I

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.206 | MFS: -2.635 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1356100)

Relative Growth Rate: 0.08 ± 0.07
Confidence: 6.63

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDQ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532402

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	2
missense	0	0	0	0

PlasmoDB Total SNPs: 192

Non-coding: 161 | Synonymous: 22 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 315 | Molecular Weight (kDa): 37.493

UniProt ID(s): Q8IDQ8

PDB ID(s): None

Isoelectric Point: 7.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A