About Gene List

PF3D7_1343300

Genome location: Pf3D7_13_v3:1,706,393..1,711,568(-)

Genome classification: Core

Function and Localization

Product Description: CDT1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.18 0.91
Trophozoite expressed 0.95 0.52
Schizont expressed 0.69 0.63
Gametocyte expressed 1.08 0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1343300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.76 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1356300)

  • Relative Growth Rate: 0.07 ± 0.11
  • Confidence: 5.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K996

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532474

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 60 28 66
disruptive 23 111 56 150
missense 13 79 51 122

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 117 50 84
disruptive 59 256 133 302
missense 32 182 103 204

PlasmoDB Total SNPs: 199

Non-coding: 137 | Synonymous: 30 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 982 | Molecular Weight (kDa): 114.585

UniProt ID(s): A0A5K1K996

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations:

Source Family ID Description
InterPro IPR014939 CDT1 Geminin-binding domain-like
InterPro IPR036390 Winged helix DNA-binding domain superfamily
PFam PF08839 CDT1 Geminin-binding domain-like
Superfamily SSF46785 Winged helix DNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108