PF3D7_1343500

Genome location: Pf3D7_13_v3:1,719,474..1,721,883(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MCNLFLNRKIILCTLYLVCLKFGHVLN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	expressed	0.21	0.85
Schizont	expressed	0.10	0.93
Gametocyte	expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1343500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.21 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8C4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139477

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	21	8	18
disruptive	5	24	18	43
missense	5	24	18	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	33	6	24
disruptive	8	62	24	76
missense	8	57	19	63

PlasmoDB Total SNPs: 162

Non-coding: 136 | Synonymous: 18 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 37.019

UniProt ID(s): A0A5K1K8C4

PDB ID(s): None

Isoelectric Point: 10.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003795	Protein of unknown function DUF192
PFam	PF02643	Protein of unknown function DUF192
Superfamily	N/A	N/A