PF3D7_1343800

Genome location: Pf3D7_13_v3:1,730,093..1,753,967(-)

Genome classification: Core

Function and Localization

Product Description: VPS13 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0019898	extrinsic component of membrane
Process	GO:0045053	protein retention in Golgi apparatus
Process	GO:0006623	protein targeting to vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.37	0.84
Trophozoite	no data	0.63	0.71
Schizont	no data	2.80	0.17
Gametocyte	no data	1.63	0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1343800

Resistome Missense Mutations: E5375D

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 5 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.279 | #Insertions: 16

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533356

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	72	433	252	565
disruptive	201	954	540	1406
missense	148	864	490	1288

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	132	810	364	632
disruptive	426	2008	830	1732
missense	284	1719	737	1451

PlasmoDB Total SNPs: 794

Non-coding: 61 | Synonymous: 420 | Nonsynonymous: 313 | Stop Codon: 0

Protein Information

Protein Length: 7594 | Molecular Weight (kDa): 905.772

UniProt ID(s): C0H5G6

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026847	Vacuolar protein sorting-associated protein 13
InterPro	IPR026854	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
InterPro	IPR031645	Vacuolar protein sorting-associated protein 13, C-terminal
PFam	PF12624	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
PFam	PF16909	Vacuolar protein sorting-associated protein 13, C-terminal
Superfamily	N/A	N/A