PF3D7_1344100

Genome location: Pf3D7_13_v3:1,763,082..1,767,594(+)

Genome classification: Core

Function and Localization

Product Description: TLD domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.27	0.87
Trophozoite	no data	0.24	0.86
Schizont	no data	0.32	0.83
Gametocyte	no data	0.46	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.13 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5G9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_143378

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	45	34	57
disruptive	20	91	56	136
missense	17	84	51	122

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	108	31	52
disruptive	40	188	105	182
missense	27	170	91	134

PlasmoDB Total SNPs: 173

Non-coding: 110 | Synonymous: 33 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 805 | Molecular Weight (kDa): 93.756

UniProt ID(s): C0H5G9

PDB ID(s): None

Isoelectric Point: 5.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006571	TLDc domain
PFam	PF07534	TLDc domain
Superfamily	N/A	N/A