PF3D7_1344300

Genome location: Pf3D7_13_v3:1,773,639..1,781,932(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.50	0.79
Trophozoite	no data	0.53	0.70
Schizont	no data	2.52	0.16
Gametocyte	no data	1.03	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.633 | #Insertions: 7

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0810900)

Relative Growth Rate: 0.22 ± 0.16
Confidence: 5.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119641

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	81	42	79
disruptive	52	258	138	314
missense	32	222	131	280

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	38	149	60	102
disruptive	107	525	235	394
missense	67	453	199	297

PlasmoDB Total SNPs: 357

Non-coding: 244 | Synonymous: 57 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 1426 | Molecular Weight (kDa): 165.75

UniProt ID(s): C0H5H1

PDB ID(s): None

Isoelectric Point: 7.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR008984	SMAD/FHA domain superfamily
InterPro	IPR011016	Zinc finger, RING-CH-type
PFam	PF00498	Forkhead-associated (FHA) domain
PFam	PF12906	Zinc finger, RING-CH-type
Superfamily	SSF49879	SMAD/FHA domain superfamily
Superfamily	SSF57850