PF3D7_1344400

Genome location: Pf3D7_13_v3:1,785,041..1,787,409(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.08	0.96
Trophozoite	no data	0.33	0.80
Schizont	no data	0.31	0.80
Gametocyte	no data	0.86	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.114 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVC8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117358

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	18	21	30
disruptive	22	114	48	113
missense	13	105	43	106

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	52	27	31
disruptive	46	198	88	158
missense	34	174	74	116

PlasmoDB Total SNPs: 149

Non-coding: 101 | Synonymous: 23 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 490 | Molecular Weight (kDa): 57.816

UniProt ID(s): A0A143ZVC8

PDB ID(s): None

Isoelectric Point: 6.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A