PF3D7_1344700

Genome location: Pf3D7_13_v3:1,790,894..1,794,920(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.60	0.71
Trophozoite	expressed	0.73	0.60
Schizont	expressed	0.30	0.81
Gametocyte	not expressed	0.64	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344700

Resistome Missense Mutations: L699M

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.963 | MFS: -1.114 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8X4

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.65) with 6JWR (Global RMSD=16.64)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533170

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	88	39	93
disruptive	60	227	142	304
missense	47	201	135	276

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	162	58	86
disruptive	90	482	193	371
missense	68	421	169	298

PlasmoDB Total SNPs: 131

Non-coding: 16 | Synonymous: 40 | Nonsynonymous: 75 | Stop Codon: 0

Protein Information

Protein Length: 1244 | Molecular Weight (kDa): 150.357

UniProt ID(s): A0A5K1K8X4

PDB ID(s): None

Isoelectric Point: 6.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A