PF3D7_1344900

Genome location: Pf3D7_13_v3:1,799,856..1,806,394(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.68	0.67
Trophozoite	expressed	0.45	0.74
Schizont	expressed	0.17	0.89
Gametocyte	expressed	0.77	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.722 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1357800)

Modification: Disrupted | RMgm-3681

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533669

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	87	54	91
disruptive	61	261	187	394
missense	31	217	156	327

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	160	68	113
disruptive	125	638	257	586
missense	73	514	208	379

PlasmoDB Total SNPs: 291

Non-coding: 115 | Synonymous: 113 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1488 | Molecular Weight (kDa): 175.997

UniProt ID(s): A0A5K1K8J8

PDB ID(s): None

Isoelectric Point: 7.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A