About Gene List

PF3D7_1344900

Genome location: Pf3D7_13_v3:1,799,856..1,806,394(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.68 0.67
Trophozoite expressed 0.45 0.74
Schizont expressed 0.17 0.89
Gametocyte expressed 0.77 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1344900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.722 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1357800)

Modification: Disrupted | RMgm-3681

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533669

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 87 54 91
disruptive 61 261 187 394
missense 31 217 156 327

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 160 68 113
disruptive 125 638 257 586
missense 73 514 208 379

PlasmoDB Total SNPs: 291

Non-coding: 115 | Synonymous: 113 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1488 | Molecular Weight (kDa): 175.997

UniProt ID(s): A0A5K1K8J8

PDB ID(s): None

Isoelectric Point: 7.18

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104