Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.68 | 0.67 |
Trophozoite | expressed | 0.45 | 0.74 |
Schizont | expressed | 0.17 | 0.89 |
Gametocyte | expressed | 0.77 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1344900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.203 | MFS: -2.722 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1357800)
Modification: Disrupted | RMgm-3681
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8J8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 13 | 87 | 54 | 91 |
disruptive | 61 | 261 | 187 | 394 |
missense | 31 | 217 | 156 | 327 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 35 | 160 | 68 | 113 |
disruptive | 125 | 638 | 257 | 586 |
missense | 73 | 514 | 208 | 379 |
PlasmoDB Total SNPs: 291
Non-coding: 115 | Synonymous: 113 | Nonsynonymous: 63 | Stop Codon: 0
Protein Length: 1488 | Molecular Weight (kDa): 175.997
UniProt ID(s): A0A5K1K8J8
PDB ID(s): None
Isoelectric Point: 7.18
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |