PF3D7_1345000

Genome location: Pf3D7_13_v3:1,806,661..1,809,617(+)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	possibly expressed	0.05	0.97
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.70	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1345000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.261 | MFS: -2.545 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1357900)

Relative Growth Rate: 1.02 ± 0.16
Confidence: 5.10

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1357900)

Modification: Disrupted | RMgm-3682

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533510

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	25	8	29
disruptive	8	49	24	59
missense	8	48	22	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	50	18	29
disruptive	21	110	50	121
missense	14	98	43	83

PlasmoDB Total SNPs: 172

Non-coding: 150 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 336 | Molecular Weight (kDa): 39.529

UniProt ID(s): C0H5H2

PDB ID(s): None

Isoelectric Point: 8.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A