PF3D7_1345300 (ApiCOX16)

Genome location: Pf3D7_13_v3:1,814,550..1,815,796(-)

Genome classification: Core

Function and Localization

Product Description: cytochrome c oxidase subunit ApiCOX16, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005751	mitochondrial respiratory chain complex IV

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.20	0.87
Schizont	no data	0.36	0.76
Gametocyte	no data	0.49	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1345300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -3.068 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1358200)

Relative Growth Rate: 0.97 ± 0.14
Confidence: 5.33

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1358200)

Modification: Disrupted | RMgm-3685

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533075

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	7	2	4
disruptive	12	4	13
missense	12	4	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	13	7	8
disruptive	1	21	8	22
missense	1	20	7	13

PlasmoDB Total SNPs: 62

Non-coding: 60 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 84 | Molecular Weight (kDa): 10.201

UniProt ID(s): C0H5H3

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A