PF3D7_1345400

Genome location: Pf3D7_13_v3:1,816,344..1,821,300(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.94
Trophozoite	expressed	1.02	0.50
Schizont	expressed	0.58	0.70
Gametocyte	expressed	0.91	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1345400

Resistome Missense Mutations: N400K

Resistome Compounds with Missense Mutations: OSM-S-106

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.244 | MFS: -2.732 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1358300)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533128

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	108	46	104
disruptive	42	277	130	294
missense	39	264	128	264

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	30	182	69	110
disruptive	102	503	174	403
missense	78	450	161	309

PlasmoDB Total SNPs: 212

Non-coding: 61 | Synonymous: 88 | Nonsynonymous: 63 | Stop Codon: 0

Protein Information

Protein Length: 1474 | Molecular Weight (kDa): 174.49

UniProt ID(s): A0A5K1K9F6

PDB ID(s): None

Isoelectric Point: 5.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A