About Gene List

PF3D7_1345600

Genome location: Pf3D7_13_v3:1,825,789..1,828,280(+)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.01 1.00
Trophozoite expressed 0.02 0.99
Schizont expressed 0.27 0.82
Gametocyte expressed 0.20 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1345600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.763 | MFS: -2.334 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Y1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532610

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 23 13 26
disruptive 12 55 36 73
missense 11 53 34 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 46 18 30
disruptive 19 98 58 95
missense 17 86 55 71

PlasmoDB Total SNPs: 138

Non-coding: 114 | Synonymous: 9 | Nonsynonymous: 12 | Stop Codon: 3

Protein Information

Protein Length: 370 | Molecular Weight (kDa): 43.22

UniProt ID(s): A0A5K1K8Y1

PDB ID(s): None

Isoelectric Point: 8

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597
22389454 Evolution and architecture of the inner membrane complex in asexual and sexualstages of the malaria parasite. Kono M, Herrmann S, ..., Gilberger TW 10.1093/molbev/mss081