About Gene List

PF3D7_1345800

Genome location: Pf3D7_13_v3:1,830,487..1,835,383(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.24 0.88
Trophozoite expressed 0.55 0.68
Schizont expressed 0.19 0.88
Gametocyte possibly expressed 0.49 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1345800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.24 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1358700)

  • Relative Growth Rate: 0.95 ± 0.15
  • Confidence: 5.12

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1358700)

Modification: Disrupted | RMgm-5340

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K976

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533195

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 88 39 81
disruptive 77 250 100 241
missense 41 183 85 194

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 140 48 81
disruptive 132 440 166 308
missense 71 340 132 203

PlasmoDB Total SNPs: 242

Non-coding: 115 | Synonymous: 57 | Nonsynonymous: 69 | Stop Codon: 1

Protein Information

Protein Length: 994 | Molecular Weight (kDa): 118.92

UniProt ID(s): A0A5K1K976

PDB ID(s): None

Isoelectric Point: 5.71

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108