PF3D7_1346000

Genome location: Pf3D7_13_v3:1,837,752..1,840,105(-)

Genome classification: Core

Function and Localization

Product Description: dynactin subunit 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005869	dynactin complex
Component	GO:0005634	nucleus
Process	GO:0007052	mitotic spindle organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.36	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1346000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.419 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1358900)

Relative Growth Rate: 1.00 ± 0.09
Confidence: 6.11

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1358900)

Modification: Disrupted | RMgm-3691

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDN7

"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=0.31) with 5Z79 (Global RMSD=21.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151767

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	45	31	57
disruptive	11	108	55	157
missense	11	103	50	150

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	91	53	57
disruptive	34	241	97	208
missense	28	211	85	142

PlasmoDB Total SNPs: 71

Non-coding: 30 | Synonymous: 19 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 695 | Molecular Weight (kDa): 82.581

UniProt ID(s): Q8IDN7

PDB ID(s): None

Isoelectric Point: 4.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR028133	Dynamitin
PFam	PF04912	Dynamitin
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108