Genome location: Pf3D7_13_v3:1,842,673..1,844,921(+)
Genome classification: Core
Product Description: protein transport protein SEC61 subunit alpha
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005784 | Sec61 translocon complex |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0008320 | protein transmembrane transporter activity |
| Function | GO:0043022 | ribosome binding |
| Function | GO:0005048 | signal sequence binding |
| Process | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation |
| Process | GO:0031204 | posttranslational protein targeting to membrane, translocation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.31 | 0.85 |
| Trophozoite | expressed | 0.53 | 0.69 |
| Schizont | expressed | 0.32 | 0.79 |
| Gametocyte | expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1346100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: -2.116 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1359000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDN6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100672
Most Similar Human Ortholog: Q9H9S3
TM-align score: 0.99 | RMSD: 0.65
Seq Identity: 0.67 | Length: 469 / 472
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000058262 | SEC61 translocon subunit alpha 1 |
| ENSG00000065665 | SEC61 translocon subunit alpha 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 47 | 18 | 37 |
| disruptive | 1 | 2 | 3 | 24 |
| missense | 1 | 2 | 3 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 94 | 23 | 27 |
| disruptive | 4 | 22 | 28 | 113 |
| missense | 2 | 13 | 20 | 29 |
PlasmoDB Total SNPs: 72
Non-coding: 48 | Synonymous: 16 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 472 | Molecular Weight (kDa): 52.224
PDB ID(s): None
Isoelectric Point: 8.79
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002208 | SecY/SEC61-alpha family |
| InterPro | IPR019561 | Translocon Sec61/SecY, plug domain |
| InterPro | IPR023201 | SecY domain superfamily |
| InterPro | IPR030659 | SecY conserved site |
| PFam | PF00344 | SecY/SEC61-alpha family |
| PFam | PF10559 | Translocon Sec61/SecY, plug domain |
| Superfamily | SSF103491 | SecY domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30127496 | Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmicreticulum translocation interactome for export to the erythrocyte. | Marapana DS, Dagley LF, ..., Cowman AF | 10.1038/s41564-018-0219-2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |