PF3D7_1346200

Genome location: Pf3D7_13_v3:1,845,502..1,847,873(-)

Genome classification: Core

Function and Localization

Product Description: nuclear import protein MOG1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1346200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.011 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1359100)

Relative Growth Rate: 0.09 ± 0.18
Confidence: 4.85

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8D5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104657

Most Similar Human Ortholog: Q9HD47

TM-align score: 0.87 | RMSD: 2.08

Seq Identity: 0.23 | Length: 162 / 168

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000108961	RAN guanine nucleotide release factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 135

Non-coding: 122 | Synonymous: 11 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 168 | Molecular Weight (kDa): 20.385

UniProt ID(s): A0A5K1K8D5

PDB ID(s): None

Isoelectric Point: 5.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007681	Ran-interacting Mog1 protein
InterPro	IPR016123	Mog1/PsbP, alpha/beta/alpha sandwich
PFam	PF04603	Ran-interacting Mog1 protein
Superfamily	SSF55724	Mog1/PsbP, alpha/beta/alpha sandwich