Genome location: Pf3D7_13_v3:1,848,215..1,851,281(+)
Genome classification: Core
Product Description: DNA/RNA-binding protein Alba 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 2.48 | 0.17 |
| Trophozoite | expressed | 1.89 | 0.22 |
| Schizont | expressed | 0.57 | 0.68 |
| Gametocyte | expressed | 0.60 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1346300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.983 | MFS: -1.756 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1359200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1359200)
Modification: Disrupted | RMgm-3694
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDN4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 140
Non-coding: 128 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 211 | Molecular Weight (kDa): 24.984
UniProt ID(s): Q8IDN4
PDB ID(s): None
Isoelectric Point: 7.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002775 | DNA/RNA-binding protein Alba-like |
| InterPro | IPR036882 | Alba-like domain superfamily |
| PFam | PF01918 | DNA/RNA-binding protein Alba-like |
| Superfamily | SSF82704 | Alba-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22167473 | PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malariaparasites. | Chene A, Vembar SS, ..., Scherf A | 10.1093/nar/gkr1215 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 21811616 | Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteinsthat interact with the translation machinery | Mani J, Guttinger A, ..., Roditi I | 10.1371/journal.pone.0022463 |