PF3D7_1346400

Genome location: Pf3D7_13_v3:1,852,631..1,871,215(+)

Genome classification: Core

Function and Localization

Product Description: VPS13 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0019898	extrinsic component of membrane
Process	GO:0045053	protein retention in Golgi apparatus
Process	GO:0006623	protein targeting to vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.47	0.42
Trophozoite	expressed	2.10	0.20
Schizont	expressed	2.62	0.18
Gametocyte	possibly expressed	2.11	0.16

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1346400

Resistome Missense Mutations: N4860H

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.989 | MFS: -2.768 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129615

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	51	365	223	418
disruptive	187	791	428	975
missense	122	703	406	887

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	109	708	291	439
disruptive	332	1466	636	1237
missense	226	1297	577	1018

PlasmoDB Total SNPs: 588

Non-coding: 41 | Synonymous: 330 | Nonsynonymous: 217 | Stop Codon: 0

Protein Information

Protein Length: 5988 | Molecular Weight (kDa): 697.051

UniProt ID(s): C0H5H6

PDB ID(s): None

Isoelectric Point: 7.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026847	Vacuolar protein sorting-associated protein 13
InterPro	IPR026854	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
PFam	PF12624	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
Superfamily	N/A	N/A