PF3D7_1346500

Genome location: Pf3D7_13_v3:1,871,485..1,873,751(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.47	0.77
Trophozoite	expressed	0.43	0.75
Schizont	possibly expressed	0.07	0.96
Gametocyte	expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1346500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.049 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1359400)

Relative Growth Rate: 0.67 ± 0.11
Confidence: 5.75

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1359400)

Modification: Disrupted | RMgm-3695

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8P9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532964

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	27	20	32
disruptive	17	112	47	127
missense	13	99	43	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	52	24	39
disruptive	38	209	71	160
missense	26	179	65	127

PlasmoDB Total SNPs: 73

Non-coding: 32 | Synonymous: 25 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 595 | Molecular Weight (kDa): 70.622

UniProt ID(s): A0A5K1K8P9

PDB ID(s): None

Isoelectric Point: 7.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A