Genome location: Pf3D7_13_v3:1,873,784..1,875,145(-)
Genome classification: Core
Product Description: respiratory chain complex 2 associated protein 4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0045273 | respiratory chain complex II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.23 | 0.85 |
| Schizont | possibly expressed | 0.29 | 0.81 |
| Gametocyte | possibly expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1346600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.937 | MFS: -0.261 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8Y5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 10 | 9 | 19 |
| disruptive | 2 | 24 | 10 | 31 |
| missense | 2 | 23 | 9 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 20 | 10 | 17 |
| disruptive | 9 | 48 | 20 | 40 |
| missense | 3 | 47 | 18 | 37 |
PlasmoDB Total SNPs: 41
Non-coding: 25 | Synonymous: 11 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 221 | Molecular Weight (kDa): 26.679
UniProt ID(s): A0A5K1K8Y5
PDB ID(s): None
Isoelectric Point: 8.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |