PF3D7_1346900

Genome location: Pf3D7_13_v3:1,881,224..1,883,036(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.18	0.88
Schizont	possibly expressed	0.25	0.82
Gametocyte	expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1346900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.968 | MFS: -2.872 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8K8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533423

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	8	7	8
disruptive	2	19	18	22
missense	2	15	18	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	21	7	14
disruptive	8	51	23	53
missense	6	43	22	36

PlasmoDB Total SNPs: 71

Non-coding: 59 | Synonymous: 8 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 251 | Molecular Weight (kDa): 29.855

UniProt ID(s): A0A5K1K8K8

PDB ID(s): None

Isoelectric Point: 5.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A