PF3D7_1347000 (WDR92)

Genome location: Pf3D7_13_v3:1,882,964..1,884,946(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein 92, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0035064	methylated histone binding
Function	GO:0043130	ubiquitin binding
Process	GO:0034968	histone lysine methylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	possibly expressed	0.03	0.98
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.521 | MFS: -2.384 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDM8

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=1.79) with 4GM8 (Global RMSD=4.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103914

Most Similar Human Ortholog: Q96MX6

TM-align score: 0.96 | RMSD: 1.35

Seq Identity: 0.38 | Length: 352 / 363

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000243667	WD repeat domain 92

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	26	7	25
disruptive	0	32	13	43
missense	0	32	13	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	43	11	34
disruptive	3	56	42	86
missense	1	49	38	73

PlasmoDB Total SNPs: 81

Non-coding: 64 | Synonymous: 15 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 363 | Molecular Weight (kDa): 41.374

UniProt ID(s): Q8IDM8

PDB ID(s): None

Isoelectric Point: 6.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily