PF3D7_1347400

Genome location: Pf3D7_13_v3:1,895,620..1,896,958(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.16	0.92
Trophozoite	no data	0.46	0.73
Schizont	no data	0.09	0.94
Gametocyte	no data	0.69	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.126 | MFS: -3.075 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_196092

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 34

Non-coding: 25 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.847

UniProt ID(s): A0A5K1K9F7

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019013	Vacuolar ATPase assembly integral membrane protein Vma21
PFam	N/A	N/A
Superfamily	N/A	N/A