Genome location: Pf3D7_13_v3:1,896,562..1,903,155(-)
Genome classification: Core
Product Description: DNA/RNA-binding protein Alba 4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0044877 | protein-containing complex binding |
| Process | GO:0006417 | regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.67 | 0.32 |
| Trophozoite | expressed | 1.56 | 0.33 |
| Schizont | expressed | 0.38 | 0.77 |
| Gametocyte | expressed | 0.71 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1347500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.068 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1360300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1366000)
Modification: Tagged | RMgm-4633
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8Y8
"Best" AlphaFill ligand hit: APR (adenosine-5-diphosphoribose, Local RMSD=0.41) with 6BXW (Global RMSD=9.78)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 346
Non-coding: 339 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 372 | Molecular Weight (kDa): 42.16
UniProt ID(s): A0A5K1K8Y8
PDB ID(s): None
Isoelectric Point: 7.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036882 | Alba-like domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF82704 | Alba-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22167473 | PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malariaparasites. | Chene A, Vembar SS, ..., Scherf A | 10.1093/nar/gkr1215 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 28787542 | ALBA4 modulates its stage-specific interactions and specific mRNA fates duringPlasmodium yoelii growth and transmission. | Munoz EE, Hart KJ, ..., Lindner SE | 10.1111/mmi.13762 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 21811616 | Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteinsthat interact with the translation machinery | Mani J, Guttinger A, ..., Roditi I | 10.1371/journal.pone.0022463 |
| 31185899 | Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi andortholog to the yeast SR-protein Gbp2 | Wippel HH, Malgarin JS, ..., Alves LR | 10.1186/s12866-019-1505-8 |
| 33493187 | An Alba-domain protein required for proteome remodelling during trypanosomedifferentiation and host transition | Bevkal S, Naguleswaran A, ..., Roditi I | 10.1371/journal.ppat.1009239 |
| 34604117 | Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage ofMalaria Parasites | Niikura M, Fukutomi T, Mitobe J, Kobayashi F | 10.3389/fcimb.2021.737457 |