PF3D7_1347600

Genome location: Pf3D7_13_v3:1,902,723..1,905,355(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.06	0.96
Schizont	no data	0.04	0.97
Gametocyte	no data	0.72	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.694 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1360400)

Relative Growth Rate: 1.07 ± 0.15
Confidence: 5.14

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1366100)

Modification: Disrupted | RMgm-4793

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171856

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	9	21
disruptive	1	32	19	46
missense	1	31	19	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	26	11	20
disruptive	10	84	45	87
missense	5	65	39	56

PlasmoDB Total SNPs: 145

Non-coding: 138 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 277 | Molecular Weight (kDa): 32.377

UniProt ID(s): C0H5H7

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A