PF3D7_1347800 (CEP72)

Genome location: Pf3D7_13_v3:1,911,507..1,912,832(+)

Genome classification: Core

Function and Localization

Product Description: centrosomal protein CEP72, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.24	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.196 | MFS: -3.295 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1108800)

Relative Growth Rate: 1.09 ± 0.18
Confidence: 4.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K981

"Best" AlphaFill ligand hit: LPA (lipoic acid, Local RMSD=4.04) with 5T8U (Global RMSD=14.63)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102611

Most Similar Human Ortholog: Q8NEP3

TM-align score: 0.91 | RMSD: 2.03

Seq Identity: 0.33 | Length: 253 / 256

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000154099	dynein axonemal assembly factor 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	16	8	19
disruptive	4	18	12	41
missense	4	17	12	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	33	11	22
disruptive	8	54	24	83
missense	7	40	22	52

PlasmoDB Total SNPs: 93

Non-coding: 83 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 30.193

UniProt ID(s): A0A5K1K981, Q2TFW5, Q2TFW6, Q2TFW7

PDB ID(s): None

Isoelectric Point: 8.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027734	Dynein assembly factor 1, axonemal
PFam	PF14580	N/A
Superfamily	SSF52075	N/A