About Gene List

PF3D7_1347900

Genome location: Pf3D7_13_v3:1,912,646..1,919,522(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.54 0.69
Schizont not expressed 0.12 0.92
Gametocyte not expressed 0.44 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1347900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.147 | MFS: -3.168 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9A2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532412

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 101 58 125
disruptive 66 287 167 378
missense 45 262 154 332

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 39 197 78 130
disruptive 129 595 291 542
missense 89 504 241 398

PlasmoDB Total SNPs: 310

Non-coding: 136 | Synonymous: 104 | Nonsynonymous: 70 | Stop Codon: 0

Protein Information

Protein Length: 1847 | Molecular Weight (kDa): 221.59

UniProt ID(s): A0A5K1K9A2

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21