PF3D7_1348000

Genome location: Pf3D7_13_v3:1,919,643..1,924,321(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.50	0.72
Gametocyte	not expressed	0.52	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.929 | MFS: -2.826 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8E9

"Best" AlphaFill ligand hit: PQJ (fos-choline-14, Local RMSD=0.06) with 6U3Y (Global RMSD=25.36)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533756

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	76	38	91
disruptive	48	205	115	293
missense	31	189	112	272

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	135	68	98
disruptive	101	410	211	372
missense	64	373	179	289

PlasmoDB Total SNPs: 193

Non-coding: 95 | Synonymous: 43 | Nonsynonymous: 55 | Stop Codon: 0

Protein Information

Protein Length: 1245 | Molecular Weight (kDa): 150.001

UniProt ID(s): A0A5K1K8E9

PDB ID(s): None

Isoelectric Point: 8.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A