PF3D7_1348100

Genome location: Pf3D7_13_v3:1,925,011..1,927,105(+)

Genome classification: Core

Function and Localization

Product Description: GTPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.5.2 (Small monomeric GTPase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005768	endosome
Function	GO:0005525	GTP binding
Function	GO:0003924	GTPase activity
Process	GO:0007264	small GTPase mediated signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.10	0.92
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.316 | MFS: -2.437 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDL8

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.14) with 1Z0D (Global RMSD=2.95)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.5.2	small monomeric GTPase	GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_123567

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	8	15	23
disruptive	3	19	6	26
missense	3	19	6	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	30	17	16
disruptive	4	39	17	51
missense	4	34	16	38

PlasmoDB Total SNPs: 129

Non-coding: 116 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 224 | Molecular Weight (kDa): 26.061

UniProt ID(s): Q8IDL8

PDB ID(s): None

Isoelectric Point: 5.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001806	Small GTPase
InterPro	IPR006073	GTP binding domain
InterPro	IPR020849	Small GTPase superfamily, Ras-type
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00071	Small GTPase
PFam	PF01926	GTP binding domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase