PF3D7_1348200

Genome location: Pf3D7_13_v3:1,927,114..1,928,445(+)

Genome classification: Core

Function and Localization

Product Description: step II splicing factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005681	spliceosomal complex
Process	GO:0008380	RNA splicing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.61	0.71
Trophozoite	possibly expressed	0.57	0.67
Schizont	possibly expressed	0.24	0.84
Gametocyte	not expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -2.89 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDL7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134700

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	8	2	11
disruptive	2	21	7	29
missense	2	20	6	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	8	20
disruptive	7	44	23	34
missense	2	33	17	26

PlasmoDB Total SNPs: 73

Non-coding: 52 | Synonymous: 14 | Nonsynonymous: 5 | Stop Codon: 2

Protein Information

Protein Length: 204 | Molecular Weight (kDa): 24.482

UniProt ID(s): Q8IDL7

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019339	CBF1-interacting co-repressor CIR, N-terminal domain
InterPro	IPR039974	Pre-mRNA-splicing factor SLU7
PFam	PF10197	CBF1-interacting co-repressor CIR, N-terminal domain
Superfamily	N/A	N/A