PF3D7_1348400

Genome location: Pf3D7_13_v3:1,935,006..1,947,401(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.25	0.89
Trophozoite	expressed	1.37	0.37
Schizont	expressed	0.54	0.73
Gametocyte	expressed	2.47	0.16

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.777 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116627

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	188	125	268
disruptive	156	617	298	747
missense	107	492	261	635

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	63	386	154	286
disruptive	301	1268	520	1050
missense	187	1002	430	740

PlasmoDB Total SNPs: 662

Non-coding: 58 | Synonymous: 333 | Nonsynonymous: 271 | Stop Codon: 0

Protein Information

Protein Length: 3855 | Molecular Weight (kDa): 460.859

UniProt ID(s): A0A5K1K8R0

PDB ID(s): None

Isoelectric Point: 7.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A