PF3D7_1348500

Genome location: Pf3D7_13_v3:1,950,044..1,952,494(+)

Genome classification: Core

Function and Localization

Product Description: TBC domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Process	GO:0090630	activation of GTPase activity
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.51	0.70
Schizont	expressed	0.20	0.86
Gametocyte	expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -2.958 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDL4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101452

Most Similar Human Ortholog: Q9NU19

TM-align score: 0.90 | RMSD: 1.78

Seq Identity: 0.41 | Length: 328 / 347

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000054611	TBC1 domain family member 22A
ENSG00000065491	TBC1 domain family member 22B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	13	26
disruptive	0	7	6	22
missense	0	6	6	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	54	17	15
disruptive	3	31	29	81
missense	2	18	23	57

PlasmoDB Total SNPs: 139

Non-coding: 122 | Synonymous: 15 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 347 | Molecular Weight (kDa): 41.207

UniProt ID(s): Q8IDL4

PDB ID(s): None

Isoelectric Point: 8.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily