PF3D7_1348800

Genome location: Pf3D7_13_v3:1,959,657..1,965,677(+)

Genome classification: Core

Function and Localization

Product Description: E1-E2 ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.09	0.95
Gametocyte	not expressed	0.71	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348800

Resistome Missense Mutations: M564I

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.492 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1367300)

Modification: Disrupted | RMgm-4787

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8L6

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=1.77) with 6JWW (Global RMSD=32.83)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533742

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	87	64	125
disruptive	50	214	120	308
missense	37	188	109	270

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	190	87	138
disruptive	109	459	197	418
missense	70	387	164	317

PlasmoDB Total SNPs: 173

Non-coding: 39 | Synonymous: 73 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 1834 | Molecular Weight (kDa): 219.273

UniProt ID(s): A0A5K1K8L6

PDB ID(s): None

Isoelectric Point: 8.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008250	P-type ATPase, A domain superfamily
InterPro	IPR023298	P-type ATPase, transmembrane domain superfamily
PFam	N/A	N/A
Superfamily	SSF81653	P-type ATPase, A domain superfamily
Superfamily	SSF81665	P-type ATPase, transmembrane domain superfamily