PF3D7_1348900

Genome location: Pf3D7_13_v3:1,965,627..1,966,386(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.16	0.90
Schizont	possibly expressed	0.03	0.98
Gametocyte	possibly expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1348900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.997 | MFS: -1.861 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Y7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533018

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	8	4	4
disruptive	2	15	10	22
missense	2	14	10	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	13	4	7
disruptive	5	37	16	29
missense	4	31	14	25

PlasmoDB Total SNPs: 29

Non-coding: 25 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 119 | Molecular Weight (kDa): 14.062

UniProt ID(s): A0A5K1K8Y7

PDB ID(s): None

Isoelectric Point: 10.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A