PF3D7_1349000

Genome location: Pf3D7_13_v3:1,966,890..1,969,427(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	0.28	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1349000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.461 | MFS: -3.156 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1361800)

Relative Growth Rate: 0.97 ± 0.19
Confidence: 4.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1361800)

Modification: Disrupted | RMgm-3704

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5H8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532680

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	30	17	36
disruptive	6	37	22	72
missense	5	34	22	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	58	23	30
disruptive	13	95	47	134
missense	7	84	44	98

PlasmoDB Total SNPs: 149

Non-coding: 118 | Synonymous: 28 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 475 | Molecular Weight (kDa): 56.245

UniProt ID(s): C0H5H8

PDB ID(s): None

Isoelectric Point: 8.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A