Product Description: cytidine and deoxycytidylate deaminase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.5.4.5 (Cytidine deaminase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0052718 | tRNA-specific adenosine-34 deaminase complex |
| Function | GO:0016787 | hydrolase activity |
| Function | GO:0052717 | tRNA-specific adenosine-34 deaminase activity |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0002100 | tRNA wobble adenosine to inosine editing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.18 | 0.89 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1349400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.808 | MFS: -3.076 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDK5
"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.10) with 7DI7 (Global RMSD=30.31)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.4.5 | cytidine deaminase | NH3GTPCTPUTPCMPSDSCDPEDTAdTTPdUTPdCMPDTNB... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100779
Most Similar Human Ortholog: Q7Z6V5
TM-align score: 0.77 | RMSD: 2.43
Seq Identity: 0.32 | Length: 164 / 232
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000189007 | adenosine deaminase tRNA specific 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 18 | 6 | 21 |
| disruptive | 5 | 31 | 13 | 57 |
| missense | 5 | 30 | 13 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 31 | 5 | 20 |
| disruptive | 10 | 67 | 37 | 59 |
| missense | 8 | 62 | 32 | 47 |
PlasmoDB Total SNPs: 143
Non-coding: 132 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 232 | Molecular Weight (kDa): 27.042
UniProt ID(s): Q8IDK5
PDB ID(s): None
Isoelectric Point: 6.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002125 | Cytidine and deoxycytidylate deaminase domain |
| InterPro | IPR016193 | Cytidine deaminase-like |
| PFam | PF00383 | Cytidine and deoxycytidylate deaminase domain |
| Superfamily | SSF53927 | Cytidine deaminase-like |
No associated publications