About Gene List

PF3D7_1349600 (SKA3)

Genome location: Pf3D7_13_v3:1,996,357..1,998,701(+)

Genome classification: Core

Function and Localization

Product Description: spindle and kinetochore-associated protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000776 kinetochore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite expressed 0.40 0.75
Schizont expressed 0.39 0.75
Gametocyte expressed 0.45 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1349600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.228 | MFS: -3.204 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1362400)

Modification: Tagged | RMgm-5112

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Z5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532736

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 16 6 27
disruptive 3 25 17 37
missense 3 24 17 35

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 36 12 26
disruptive 5 79 23 87
missense 5 68 20 52

PlasmoDB Total SNPs: 158

Non-coding: 139 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 35.987

UniProt ID(s): A0A5K1K8Z5

PDB ID(s): None

Isoelectric Point: 5.66

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36006241 Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation Brusini L, Dos Santos Pacheco N, ..., Brochet M 10.1083/jcb.202111084